Figure 3 | Scientific Reports

Figure 3

From: α-Mangostin-encapsulated PLGA nanoparticles inhibit pancreatic carcinogenesis by targeting cancer stem cells in human, and transgenic (KrasG12D, and KrasG12D/tp53R270H) mice

Figure 3

Mang-NPs inhibit colony formation and induce apoptosis in pancreatic CSCs and cancer cell lines.

(A) Pancreatic CSCs (Pan CSCs), and cancer cell lines (PANC-1, AsPC-1, and MIA PaCa-2) were treated with Mang-NPs (0–10 μM) for 21 days. Number of colonies were counted. Data represent mean ± SD. *, # and % = significantly different from control, and each other, P < 0.05. (B) Pan CSCs, and cancer cell lines (PANC-1, AsPC-1, and MIA PaCa-2) were treated with Mang-NPs (0–10 μM) for 48 hrs. Apoptosis was measured by TUNEL assay. Data represent mean ± SD. *, # and % = significantly different from control, and each other, P < 0.05.

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