Figure 1 | Scientific Reports

Figure 1

From: Distinct roles of exogenous opioid agonists and endogenous opioid peptides in the peripheral control of neuropathy-triggered heat pain

Figure 1

Development of mechanical hypersensitivity in wild-type and opioid peptide-lacking mice.

The effects were measured using von Frey filaments in hind paws ipsilateral to the CCI or sham surgery in wild-type, END-KO, PENK-KO or PDYN-KO mice. *P < 0.05 compared to the corresponding thresholds before CCI surgery and to those in sham-operated mice; †P < 0.05 compared to the corresponding wild-type mice (two-way repeated measures ANOVA, Bonferroni test). There were no significant differences in sham-operated groups (P > 0.05, two-way repeated measures ANOVA). Detailed statistical analysis is presented in Supplementary Table 1. Data are expressed as mean ± SEM. N = 6–8 mice per group.

Back to article page