Figure 2 | Scientific Reports

Figure 2

From: Distinct roles of exogenous opioid agonists and endogenous opioid peptides in the peripheral control of neuropathy-triggered heat pain

Figure 2

Effects of CRF on mechanical hypersensitivity in wild-type and opioid peptide-lacking mice.

CFR was injected at the CCI site on days 2 and 14 following CCI, and effects were assessed 30 min after injection using von Frey filaments in hind paws ipsilateral to the CCI of wild-type, END-KO, PENK-KO or PDYN-KO mice. *P < 0.05 compared to thresholds before CCI (indicated by dashed lines) (paired t-test or Wilcoxon test); #P < 0.05, compared to the respective vehicle-treated groups; †P < 0.05 compared to the corresponding wild-type mice (Mann-Whitney U test). Data are expressed as mean ± SEM. N = 6–8 mice per group.

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