Figure 3 | Scientific Reports

Figure 3

From: Distinct roles of exogenous opioid agonists and endogenous opioid peptides in the peripheral control of neuropathy-triggered heat pain

Figure 3

Effects of CRF on heat hypersensitivity in wild-type mice.

(A) Dose-dependency assessed 5 min after CFR injection. *P < 0.05 compared to latencies before CCI (indicated by dashed lines) (paired t-test or Wilcoxon test); #P < 0.05 compared to vehicle-treated group (0 ng) (one-way ANOVA, Bonferroni test). (B) Time-course of CFR (100 ng) effects. *P < 0.05 compared to latencies before CCI; #P < 0.05, compared to vehicle-treated group (two-way repeated measures ANOVA, Bonferroni test). In all experiments, CRF was applied at the CCI site and the effects were assessed using Hargreaves test, in hind paws ipsilateral to the CCI on days 2 and 14. Detailed statistical evaluation is presented in Supplementary Table 2. Data are expressed as mean ± SEM. N = 6 mice per group.

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