Figure 5 | Scientific Reports

Figure 5

From: Distinct roles of exogenous opioid agonists and endogenous opioid peptides in the peripheral control of neuropathy-triggered heat pain

Figure 5

Effects of exogenous opioid receptor agonists on heat hypersensitivity in wild-type and opioid peptide-lacking mice.

DAMGO, DPDPE and U50, 488H were injected at the CCI site on days 2 and 14 following CCI, and effects were assessed 5 min after injection using Hargreaves test, in hind paws ipsilateral to the CCI of wild-type, END-KO, PENK-KO or PDYN-KO mice. Dashed lines represent latencies determined before CCI. #P < 0.05 compared to the corresponding vehicle-treated groups (two-way ANOVA, Bonferroni test). Detailed statistical evaluation is presented in Supplementary Table 4. Data are expressed as mean ± SEM. N = 8–9 mice per group.

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