Figure 3

ELISA Validation of Extrinsic Pathway Proteins.

Seven proteins analyzed by ELISA displayed significant changes between MDD-SA, MDD-NA, and HC samples (n = 49 each). (A) FVII, (B) FV, (C) APC, (D) soluble TF, and (E) TFPI were significantly upregulated in MDD-SA subjects compared to both MDD-NA and HC subjects. (F) F1 + 2 was significantly upregulated in MDD-SA compared to MDD-NA subjects and downregulated in MDD-SA compared to HC. (G) There was no significant changes in prothrombin among the three groups. A single asterisk (*) indicates significant change with p < 0.05, ** indicates p < 0.01, and *** indicates p = 0.000. Acronyms: ELISA, enzyme-linked immunosorbent assay; MDD-SA, majorly depressed suicide attempter; MDD-NA, majorly depressed non-attempter; HC, healthy control; TF, tissue factor; TFPI, tissue factor pathway inhibitor; FVII; coagulation factor FVII; APC, activated protein C; F1 + 2, prothrombin fragment 1 + 2.