Figure 6

Extrinsic Pathway Differentiators and Relative Prothrombinase Activity.

Based on the mean values of F1 + 2 and prothrombin from the three groups, HC subjects displayed higher relative prothrombinase activity than both MDD-SA and MDD-NA subjects, and MDD-SA subjects displayed a higher relative prothrombinase activity than MDD-NA subjects. ^*The relative mass-action ratio applied here, Γr = [F1 + 2]²/[prothrombin]_x)/([F1 + 2]²_MDD-NA/[prothrombin]_MDD-NA, was derived from the prothrombinase reaction (i.e., prothrombin → F1 + 2 + thrombin) with a 1:1 molar equivalency of the F1 + 2 and thrombin products, leading to the [F1 + 2]-squared term. As opposed to simply comparing F1 + 2 levels, this ratio was applied as a more accurate metric of relative prothrombinase activity to control for intergroup variations in prothrombin levels. Acronyms: MDD-SA, majorly depressed suicide attempter; MDD-NA, majorly depressed non-attempter; HC, healthy control; F1 + 2, prothrombin fragment 1 + 2.