Figure 1
From: Incomplete immune response to coxsackie B viruses associates with early autoimmunity against insulin
Antibody responses against CVB capsid proteins.
Antibody titers against VPs of CVB1-6 are represented as a heat map where each vertical line is a sample (n = 440), and the intensity of the color corresponds to the relative light units (RLU) immunoprecipitated in the LIPS assay. Four clusters were identified by hierarchical clustering of Euclidean distances calculated from anti-VP1 and anti-VP2 antibody titers. The clusters represent samples with weak responses to VP1 and/or VP2 (cluster 1, weak), samples with strong and dominant VP2 antibody responses (cluster 2, VP2), samples with strong and dominant VP1 antibody responses (cluster 3, VP1), and samples with strong VP1 and VP2 antibody responses (cluster 4, VP1/VP2). Within each cluster, there is a small subset of samples with strong antibodies to VP4.
