Figure 2 | Scientific Reports

Figure 2

From: Incomplete immune response to coxsackie B viruses associates with early autoimmunity against insulin

Figure 2

Anti-VP1 antibodies inhibit CVB plaque formation.

Plaque neutralization tests using CVB3 were performed with 8 representative sera that were selected based on their anti-CVB profile (Supplementary Fig. 3) as strong anti-VP2 and VP1 antibodies (filled symbols), or strong anti-VP2 antibodies only (open symbols). Despite similar anti-VP2 titers in each serum, the anti-VP1 high titer sera had >100-fold stronger neutralization capacity than the anti-VP1 deficient sera. ****p-value < 0.0001 based on repeated measures ANOVA with Bonferroni post-test comparisons.

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