Figure 2
From: Nicotine regulates activity of lateral habenula neurons via presynaptic and postsynaptic mechanisms
nAChR subtypes mediating nicotine effects in LHb.
(A) Nicotine-induced inward currents were blocked by MEC, α-CTx-MII, MII[H9A; L15A] and DHβE, but not MLA. (B) Nicotine-induced increases in firing rate was prominently reduced by MEC, and MII [H9A; L15A], and weakly but significantly reduced by MLA. (C,D) Summary of above data. (E) Local ACh application induced an MII [H9A; L15A]-sensitive inward current. *p < 0.05, **p < 0.01, ***p < 0.001.
