Table 4 Multivariable-adjusted relative risk of cardiovascular disease in relation to frequency of bowel movements according to baseline characteristics in the Nurses’ Health Study (1982–2012)*.
Frequency of bowel movements | P for trend | P for interaction | |||||
---|---|---|---|---|---|---|---|
> 1/Day | Daily | Every 2 days | Every 3–4 days | Every 5 days or less | |||
Age | 0.01 | ||||||
≥48 years (Case = 5759) | 0.98 (0.91, 1.07) | 1.00 (reference) | 0.97 (0.90, 1.04) | 0.93 (0.83, 1.04) | 0.90 (0.69, 1.17) | 0.45 | |
<48 years (Case = 1869) | 1.25 (1.09, 1.43) | 1.00 (reference) | 0.94 (0.83, 1.07) | 1.14 (0.96, 1.35) | 1.08 (0.73, 1.61) | 0.01 | |
Body mass index | 0.18 | ||||||
≥30 kg/m2 (Case = 1413) | 0.96 (0.84, 1.10) | 1.00 (reference) | 0.95 (0.80, 1.13) | 1.08 (0.84, 1.39) | 0.79 (0.41, 1.52) | 0.72 | |
25–30 kg/m2 (Case = 2216) | 1.20 (1.06, 1.36) | 1.00 (reference) | 1.04 (0.93, 1.17) | 0.92 (0.76, 1.11) | 1.06 (0.70, 1.59) | 0.01 | |
<25 kg/m2 (Case = 5566) | 1.03 (0.92, 1.15) | 1.00 (reference) | 0.92 (0.85, 1.01) | 0.98 (0.87, 1.11) | 0.95 (0.71, 1.26) | 0.13 | |
Smoking status | 0.47 | ||||||
Current smokers (Case = 2783) | 1.00 (0.88, 1.12) | 1.00 (reference) | 0.98 (0.87, 1.09) | 1.02 (0.87, 1.19) | 1.10 (0.78, 1.54) | 0.98 | |
Non-current smokers (Case = 4819) | 1.08 (0.99, 1.18) | 1.00 (reference) | 0.96 (0.89, 1.04) | 0.98 (0.87, 1.11) | 0.88 (0.66, 1.17) | 0.02 | |
Alcohol intake | 0.12 | ||||||
Drinkers (Case = 5262) | 1.05 (0.97, 1.15) | 1.00 (reference) | 0.93 (0.86, 1.01) | 0.94 (0.83, 1.05) | 1.11 (0.86, 1.42) | 0.03 | |
Non-drinkers (Case = 2340) | 1.04 (0.92, 1.18) | 1.00 (reference) | 1.03 (0.92, 1.15) | 1.08 (0.91, 1.27) | 0.68 (0.43, 1.05) | 0.74 | |
Physical activity | 0.37 | ||||||
≥1.5 h/week (Case = 3411) | 1.07 (0.97, 1.19) | 1.00 (reference) | 0.96 (0.87, 1.06) | 1.04 (0.90, 1.21) | 1.20 (0.88, 1.65) | 0.28 | |
<1.5 h/week (Case = 4124) | 1.03 (0.94, 1.14) | 1.00 (reference) | 0.96 (0.88, 1.05) | 0.94 (0.83, 1.06) | 0.81 (0.59, 1.10) | 0.09 | |
Hypertension | 0.88 | ||||||
Hypertensive (Case = 2546) | 1.10 (0.99, 1.23) | 1.00 (reference) | 0.96 (0.85, 1.08) | 1.03 (0.86, 1.22) | 1.01 (0.66, 1.52) | 0.08 | |
Non-hypertensive (Case = 4989) | 1.03 (0.94, 1.12) | 1.00 (reference) | 0.96 (0.89, 1.04) | 0.96 (0.85, 1.07) | 0.94 (0.73, 1.22) | 0.18 | |
Diabetes | 0.18 | ||||||
Diabetic (Case = 594) | 0.97 (0.78, 1.21) | 1.00 (reference) | 1.02 (0.80, 1.31) | 1.19 (0.84, 1.69) | 1.29 (0.62, 2.71) | 0.43 | |
Non-diabetic (Case = 6941) | 1.06 (0.99, 1.14) | 1.00 (reference) | 0.96 (0.89, 1.02) | 0.96 (0.87, 1.06) | 0.93 (0.74, 1.18) | 0.01 | |
Laxative use | 0.14 | ||||||
Users (Case = 820) | 1.23 (0.94, 1.62) | 1.00 (reference) | 0.92 (0.78, 1.09) | 0.83 (0.68, 1.02) | 0.74 (0.50, 1.11) | 0.005 | |
Non-users (Case = 5317) | 1.03 (0.95, 1.11) | 1.00 (reference) | 0.97 (0.89, 1.05) | 1.10 (0.96, 1.26) | 0.99 (0.68, 1.43) | 0.55 | |
Total fiber intake | 0.59 | ||||||
≥15.7 g/d (Case = 2347) | 0.99 (0.87, 1.12) | 1.00 (reference) | 0.97 (0.86, 1.09) | 0.90 (0.75, 1.09) | 0.83 (0.53, 1.29) | 0.55 | |
<15.7 g/d (Case = 2268) | 1.06 (0.94, 1.20) | 1.00 (reference) | 0.94 (0.83, 1.07) | 1.11 (0.94, 1.31) | 0.83 (0.54, 1.28) | 0.37 | |
Red meat intake | 0.005 | ||||||
≥1.28 serving/d (Case = 2372) | 0.88 (0.78, 1.00) | 1.00 (reference) | 0.88 (0.78, 1.00) | 0.91 (0.76, 1.10) | 0.75 (0.47, 1.17) | 0.83 | |
<1.28 serving/d (Case = 2241) | 1.20 (1.06, 1.35) | 1.00 (reference) | 1.05 (0.93, 1.18) | 1.12 (0.94, 1.33) | 0.93 (0.61, 1.42) | 0.09 | |
Total energy intake | 0.72 | ||||||
≥1509 kcal/d (Case = 2369) | 0.97 (0.87, 1.10) | 1.00 (reference) | 0.98 (0.87, 1.11) | 1.08 (0.90, 1.29) | 0.85 (0.53, 1.35) | 0.65 | |
<1509 kcal/d (Case = 2246) | 1.08 (0.95, 1.23) | 1.00 (reference) | 0.92 (0.82, 1.04) | 0.96 (0.80, 1.14) | 0.81 (0.54, 1.22) | 0.04 | |
Alternate Healthy Eating Index score | 0.03 | ||||||
≥33.1 (Case = 2670) | 1.15 (1.03, 1.28) | 1.00 (reference) | 1.00 (0.90, 1.12) | 1.06 (0.90, 1.25) | 0.87 (0.58, 1.30) | 0.05 | |
<33.1 (Case = 2720) | 0.92 (0.82, 1.04) | 1.00 (reference) | 0.87 (0.78, 0.98) | 0.89 (0.75, 1.05) | 0.72 (0.48, 1.09) | 0.44 |