Table 2 Regression coefficients of tertiles of cotinine level for hearing threshold.

		High-PTA				Low-PTA
Variables		Unadjusted	Model 1	Model 2	Model 3	Unadjusted	Model 1	Model 2	Model 3
Tertile of serum cotinine level
Tertile 1	β^* (95%CI)	Reference	Reference	Reference	Reference	Reference	Reference	Reference	Reference
Tertile 1	P value	—	—	—	—	—	—	—	—
Tertile 2	β (95%CI)	0.021 (−0.016,0.058)	0.005 (−0.027,0.037)	0.010 (−0.021,0.042)	0.012 (−0.019,0.044)	−0.016(−0.049,0.017)	−0.015 (−0.047,0.017)	−0.013 (−0.045,0.020)	−0.010 (−0.042,0.022)
Tertile 2	P value	0.257	0.756	0.530	0.442	0.348	0.357	0.444	0.548
Tertile 3	β (95%CI)	0.026 (−0.010,0.063)	0.045 (0.013,0.076)	0.049 (0.017,0.081)	0.049 (0.017,0.081)	0.026 (−0.006,0.059)	0.042 (0.010,0.075)	0.040 (0.008,0.073)	0.041 (0.008,0.073)
Tertile 3	P value	0.161	0.006	0.003	0.002	0.114	0.010	0.016	0.014
P for trend		0.163	0.006	0.003	0.002	0.109	0.010	0.015	0.013

Adjusted covariates: Model 1 = age, sex, race.
Model 2 = Model 1 + (BMI, HDL-C, uric acid, waist circumference).
Model 3 = Model 2 + (abnormal otoscopy, abnormal tympanometry, present use of ototoxic agents, history of diabetes, heart disease, stroke).
Definition of abbreviations: High-PTA = Pure tone average at high frequencies, Low-PTA = Pure tone average at low frequencies, BMI = body mass index, HDL-C = high-density lipoprotein cholesterol.
*β Coefficients can be interpreted as differences in hearing threshold comparing subjects in the upper two cotinine level quartiles to those in the lowest quartile.

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