Table 1 Physiological and biochemical characteristics in experiment rats.

From: The enhanced atorvastatin hepatotoxicity in diabetic rats was partly attributed to the upregulated hepatic Cyp3a and SLCO1B1

Parameter

CON

HFD

DM

DM-AL

DM-AM

Body weight (g)

239.3 ± 12.2

305.3 ± 10.2**

290.2 ± 20.6**

269.3 ± 5.3**

250.8 ± 22.4

Liver weight (% of body weight)

2.85 ± 0.16

4.71 ± 0.22**

5.46 ± 0.27**

6.94 ± 0.95**##

10.60 ± 2.25**##

Spleen weight (% of body weight)

0.198 ± 0.027

0. 215 ± 0.010

0.218 ± 0.024

0.264 ± 0.027**#

0.392 ± 0.033**##

FBG (mM)

7.53 ± 0.34

7.76 ± 0.65

16.92 ± 1.35**

18.38 ± 1.75**

18.34 ± 1.60**

FINS (mIU/L)

29.20 ± 3.06

30.12 ± 2.41

34.42 ± 3.99

32.65 ± 2.15

32.51 ± 4.45

HOMA-IR

9.56 ± 1.05

10.32 ± 1.25

25.51 ± 1.79**

27.56 ± 2.01**

26.92 ± 2.52**

TC (mM)

1.88 ± 0.14

2.82 ± 0.72*

7.98 ± 1.64**

4.02 ± 0.71**##

3.42 ± 0.52**##

TG (mM)

1.23 ± 0.14

2.56 ± 0.30**

7.00 ± 1.76**

5.40 ± 0.50**

3.75 ± 0.70**##

  1. Data are represented means ± SD (n = 5) *p < 0.05, **p < 0.01 vs. CON, #p < 0.05, ##p < 0.01 vs. DM rats. Symbols: CON, normal rats; HFD, high-fat diet fed rats; DM, diabetic rats; DM-AL, diabetic rats treated with 10 mg/kg atorvastatin and DM-AM, diabetic rats treated with 20 mg/kg atorvastatin.
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