Figure 6
From: Upregulation of CYP2S1 by oxaliplatin is associated with p53 status in colorectal cancer cell lines
Inhibition of the growth of colorectal tumor cells by oxaliplatin treatment.
When CRC cells are exposed to oxaliplatin, activation of p53 leads to upregulation of CYP2S1 transcription and translation and a decrease in endogenous PGE2 biosynthesis and β-catenin expression, which ultimately decreases colorectal cell survival and proliferation.
