Figure 2
From: Vitamin D Supplementation for Patients with Dry Eye Syndrome Refractory to Conventional Treatment
The effects of vitamin D supplementation on dry eye syndrome according to gender.
(A) Tear break-up time (TBUT) in males was longer at 2 weeks compared to pre-treatment and that in female was longer at 2 and 6 weeks compared to pre-treatment (p = 0.041, <0.001 and <0.001, respectively, paired t-test). (B) Fluorescein staining score (FSS) in men was not different during the observational period but in women it was decreased at 2 weeks compared to pretreatment. (C) Hyperemia of the eyelid margin in men was lower at 6 and 10 weeks compared to pre-treatment and in women it was lower at 2 and 6 weeks compared to pre-treatment (p = 0.012, 0.030, <0.001 and <0.001, respectively, paired t-test). (D) Tear secretion in men was not different during the observational period, in women was increased at 2 and 6 weeks compared to pre-treatment (p = 0.009 and 0.011, respectively, paired t-test). (E) Ocular surface disease index (OSDI) score in men was lower at 6 weeks compared to pre-treatment; in women it was lower at 10 weeks compared to pre-treatment (p = 0.033 and 0.012, respectively, paired t-test). (F) Visual analogue pain score (VAS) in men did not different during the observational period; in women it was lower at 2 and 6 weeks compared to pre-treatment (p = 0.011 and 0.034, respectively, paired t-test). (G) Severity of symptoms in men was lower at 6 and 10 weeks; and in women it was lower at 2 and 6 weeks compared to pre-treatment (p = 0.043, 0.038, 0.017 and 0.014, respectively, paired t-test). (H) Duration of symptoms in men was lower at 6 weeks compared to pre-treatment; in women it was lower at 2 and 6 weeks compared to pre-treatment (p = 0.021, 0.004 and 0.021, respectively, paired t-test).
