Table 4 Cox regression analysis (backwards stepwise model) summarizing significant independent prognostic factors for BF, CF and PCD in PCa patients (n = 535), significant p values in bold (0.05 threshold).
From: Estrogen receptors α and β and aromatase as independent predictors for prostate cancer outcome
Marker | BF (n = 170) | CF (n = 36) | PCD (n = 15) | |||
|---|---|---|---|---|---|---|
HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | |
pT - stage | <0.001 | |||||
pT2 | 1 | NE | NE | |||
pT3a | 1.81 (1.22–2.63) | 0.003 | ||||
pT3b | 2.84 (1.74–4.65) | <0.001 | ||||
Gleason grade | 0.055 | 0.019 | 0.085 | |||
3 + 3 | 1 | 1 | 1 | |||
3 + 4 | 1.02 (0.68–1.51) | 0.922 | 2.12 (0.74–1.20) | 0.160 | 3.55 (0.39–32.03) | 0.26 |
4 + 3 | 1.45 (0.90–2.30) | 0.127 | 3.00 (0.94–9.56) | 0.063 | 9.05 (1.02–80.52) | 0.048 |
4 + 4 | 1.28 (0.61–2.70) | 0.513 | 2.89 (0.55–15.14) | 0.210 | 5.97 (0.36–100.39) | 0.22 |
≥9 | 2.27 (1.25–4.12) | 0.007 | 6.80 (2.17–21.32) | 0.001 | 15.67 (1.70–144.62) | 0.015 |
PNI | NE | 2.12 (1.03–4.39) | 0.043 | 3.4 (1.1–10.53) | 0.034 | |
Preop. PSA | 1.37 (0.99–1.91) | 0.057 | NE | NE | ||
Apical PSM | 0.69 (0.49–0.98) | 0.038 | NE | NE | ||
Non-apical PSM | 1.72 (1.21–2.44) | 0.002 | 3.16 (1.52–6.60) | 0.002 | NE | |
ERβ TS | 1.70 (1.19–2.42) | 0.004 | NE | NE | ||
Aromatase TS | 0.55 (0.38–0.80) | 0.002 | NE | NE | ||
Aromatase TE | NE | 0.43 (0.21–0.90) | 0.024 | 0.33 (0.10–1.04) | 0.059 | |
ERα TS | NE | 0.43 (0.22–0.87) | 0.018 | 0.28 (0.10–0.78) | 0.015 | |
