Figure 5
Kaplan Meier curves of cumulative CVD-free survival or mortality free survival depending on the MCM6-rs3754686 polymorphism and sex in the PREDIMED participants.
N = 3065 men and n = 4120 women were analyzed: (A) CVD incidence in men, (B) CVD incidence in women, (C) total mortality in men and (D), total mortality in women. Multivariable Cox regression models with outcome of CVD incidence or total mortality were fitted as indicated in methods. HR and 95% CI were obtained in the multivariable adjusted models: HR1: Model 1 (adjusted for sex, age, field center and dietary intervention group) and HR2: Model 2 (adjusted for variables in model 1 plus BMI, diabetes, drinking, smoking, physical activity, medication (hypertension, dyslipemia and glucose) and total energy intake at baseline). For these estimations, as well for the interaction terms, a recessive model was computed. P for interactions between the MCM6 SNP and sex in the corresponding multivariable adjusted Cox regression model were P = 0.005 for CVD, and P = 0.032 for total mortality in Model 2.
