Table 3 Associations of MCM6-rs3754686 proxy for milk intake with fasting glucose and lipids*.

From: Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization

 

BPRHS

GOLDN

CC (485)

CT (553)

TT (194)

P1

P2

CC (56)

CT (333)

TT (428)

P1

P2

Glucose, mg/dL

127 ± 3

120 ± 2

115 ± 4

0.036

0.032

103 ± 2

103 ± 1

101 ± 1

0.479

0.091

Total cholesterol, mg/dL

181 ± 2

181 ± 2

179 ± 3

0.914

0.968

197 ± 5

195 ± 2

191 ± 2

0.225

0.216

LDL-C, mg/dL

105 ± 2

105 ± 2

105 ± 3

0.981

0.939

127 ± 4

125 ± 2

123 ± 2

0.518

0.470

HDL-C, mg/dL

43.8 ± 0.6

44.3 ± 0.5

41.7 ± 0.9

0.038

0.041

46.9 ± 1.7

46.0 ± 0.7

45.9 ± 0.7

0.855

0.827

Triglycerides, mg/dL

168 ± 6

163 ± 5

169 ± 9

0.637

0.859

144 ± 11

142 ± 6

142 ± 5

0.894

0.827

 

PREDIMED

WHI

CC (1594)

CT (3399)

TT (1927)

P1

P2

CC (600)

CT (518)

TT (124)

P1

P2

Glucose, mg/dL

121 ± 40

123 ± 42

120 ± 41

0.421

0.793

106 ± 1

106 ± 2

103 ± 3

0.562

0.923

Total cholesterol, mg/dL

211 ± 38

211 ± 38

212 ± 42

0.763

0.722

222 ± 2

218 ± 2

220 ± 4

0.277

0.159

LDL-C, mg/dL

131 ± 34

130 ± 34

131 ± 38

0.922

0.551

138 ± 2

134 ± 2

135 ± 3

0.219

0.153

HDL-C, mg/dL

53.3 ± 13.5

53.9 ± 14.0

54.2 ± 14.7

0.045

0.044

57.0 ± 0.6

57.2 ± 0.6

58.0 ± 1.3

0.765

0.756

Triglycerides, mg/dL

139 ± 85

136 ± 75

138 ± 82

0.989

0.591

136 ± 3

135 ± 3

130 ± 6

0.828

0.429

  1. *Values are means ± Standard Error of Mean. The rs3754686 SNP was determined in the PREDIMED Study and imputed in the BPRHS. The proxy SNP rs309180 was used in GOLDN and WHI studies.
  2. **General Linear Regression models with multivariable adjustment for the indicated covariates were fitted for each population.
  3. 1P adjusted by sex, age, field center or race.
  4. 2P adjusted for sex, age, field center or ancestry (BPRHS, WHI), family (GOLDN), BMI, smoking, drinking, physical activity, diabetes, medication and total energy intake.
  5. In PREDIMED, some variables (glucose, LDL-C, HDL-C and triglycerides) included missing data point. Biochemical data were available for fasting glucose (n = 6801 participants) total cholesterol (n = 6920 participants), HDL cholesterol (n = 6837 participants), LDL cholesterol (n = 6782 participants), and triglycerides (n = 6881 participants).
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