Figure 5
Syn displays sequence similarities with stathmin.
Multiple alignment of Syn with four members of stathmin family was performed by ClustalW. Blue lines delimitate the domains of stathmin family involved in tubulin binding. Arrows mark the sites of Syn pathological mutations: Ala30 (green arrow), the conserved Glu46 and Ala53 (red arrows), His50 and Gly51 (blue arrows). Asterisks mark invariant positions, while dots and colons highlight semi-conservative and conservative substitutions, respectively.
