Figure 7
Model for Syn/MTs interaction.
Syn senses and binds free tubulin dimers forming a specific complex with tubulin α2β2 tetramer and acquiring α-helix conformation (STEP 1). Afterwards, Syn behaves like a tubulin deliverer promoting MT nucleation (STEP 2-High [Tub]free). When entrapped in the MT wall, Syn promotes MT catastrophes probably inducing changes in intra- or inter-dimer angles (STEP 2-Low [Tub]free).
