Table 3 Association analyses of missense variants.

From: Mutation screening of GRIN2B in schizophrenia and autism spectrum disorder in a Japanese population

Genomic data

SCZ (n = 4145)

ASD (n = 381)

CON (n = 4432)

Variant

Position

Ma/ma

MAF

Genotype countb

P valuec

MAF

Genotype countb

P valuec

MAF

Genotype countb

V18I

13866157

G/A

0.004

0/32/4078

1

0.0014

0/1/365

0.94

0.0041

0/35/4371

A590T

13611737

G/A

N/A

0/0/4106

0.5

N/A

0/0/363

1

0.0002

0/2/4403

G1040S

13564120

G/A

0.0003

0/2/4108

1

N/A

0/0/363

1

0.0004

0/3/4394

R1099H

13563942

G/A

0.0001

0/1/4117

0.96

N/A

0/0/363

1

0.0005

0/4/4399

K1292R

13563363

A/G

0.0004

0/3/4108

0.11

N/A

0/0/363

1

N/A

0/0/4393

  1. Abbreviations: SCZ, schizophrenia; ASD, autism spectrum disorders ; N/A, not applicable; MAF, minor allele frequency.
  2. aM, major allele; m, minor allele.
  3. bGenotype count; homozygote of major allele/heterozygote/homozygote of minor allele.
  4. cP values were calculated by Fisher’s exact test (2 × 2 contingency table, two-tailed).
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