Table 1 Suggestively significant interactions between Y-hg O3e* and SNPs in control and case groups.

From: Y chromosome haplogroups based genome-wide association study pinpoints revelation for interactions on non-obstructive azoospermia

Chr

SNPa

MAFb

MAFc

ORSNP

P SNP

ORO3e*

P O3e*

ORinter

P inter

R2

2

rs13017562

0.38

0.36

0.93

0.26

0.31

3.63 × 10−8

2.22

2.62 × 10−5

0.064

2

rs869633

0.38

0.36

0.93

0.26

0.31

3.72 × 10−8

2.22

2.69 × 10−5

0.064

2

rs869632

0.38

0.36

0.94

0.29

0.32

4.69 × 10−8

2.18

3.68 × 10−5

0.063

2

rs815808

0.06

0.09

0.91

0.37

0.45

1.10 × 10−7

3.42

3.05 × 10−5

0.065

2

rs815807

0.05

0.08

0.91

0.40

0.46

2.08 × 10−7

3.36

6.83 × 10−5

0.063

2

rs1723493

0.04

0.08

0.91

0.45

0.47

2.28 × 10−7

3.34

9.03 × 10−5

0.063

2

rs11678378

0.44

0.43

1.00

0.99

1.12

0.560

0.46

7.63 × 10−5

0.063

3

rs17217643

0.31

0.33

0.87

0.03

0.35

5.42 × 10−8

2.26

5.25 × 10−5

0.063

3

rs6774209

0.31

0.33

0.87

0.03

0.34

4.45 × 10−8

2.24

9.16 × 10−5

0.065

3

rs10513814

0.19

0.20

0.86

0.07

0.41

1.08 × 10−7

2.30

9.75 × 10−5

0.062

4

rs17005650

0.33

0.37

1.05

0.44

0.32

5.99 × 10−8

2.26

3.47 × 10−5

0.066

5

rs11135482

0.39

0.42

0.83

4.93 × 10−3

0.31

1.02 × 10−7

2.07

9.11 × 10−5

0.064

5

rs11135484

0.39

0.43

0.80

9.09 × 10−4

0.31

1.56 × 10−7

2.07

9.89 × 10−5

0.065

5

rs12520985

0.23

0.24

1.11

0.14

0.89

0.455

0.38

7.15 × 10−5

0.064

5

rs13181162

0.41

0.41

0.94

0.31

0.30

1.36 × 10−7

2.10

9.36 × 10−5

0.062

6

rs16891417

0.09

0.06

0.91

0.44

0.49

5.41 × 10−7

4.52

7.07 × 10−5

0.063

6

rs3818947

0.08

0.06

0.89

0.38

0.49

5.54 × 10−7

4.58

6.26 × 10−5

0.063

6

rs16891497

0.09

0.06

0.95

0.69

0.48

3.37 × 10−7

4.45

4.41 × 10−5

0.063

6

rs16891501

0.09

0.06

0.86

0.25

0.49

5.48 × 10−7

4.23

7.95 × 10−5

0.062

6

rs9452333

0.34

0.42

1.02

0.77

1.04

0.847

0.47

9.88 × 10−5

0.063

7

rs17139327

0.22

0.25

0.85

0.03

0.39

5.83 × 10−8

2.42

6.11 × 10−5

0.064

8

rs10957317

0.15

0.15

0.86

0.08

0.42

5.78 × 10−8

2.79

3.05 × 10−5

0.063

8

rs12545097

0.15

0.15

0.86

0.09

0.41

3.63 × 10−8

2.95

1.20 × 10−5

0.064

8

rs2385127

0.15

0.15

0.85

0.07

0.42

4.95 × 10−8

2.88

1.92 × 10−5

0.064

9

rs2117103

0.18

0.19

0.93

0.34

0.40

6.98 × 10−8

2.37

6.17 × 10−5

0.063

9

rs1368677

0.18

0.19

0.91

0.26

0.40

6.65 × 10−8

2.40

4.77 × 10−5

0.063

9

rs12555036

0.42

0.44

0.94

0.29

0.29

1.36 × 10−7

2.08

8.48 × 10−5

0.063

11

rs4757259

0.30

0.26

0.86

0.04

0.38

6.48 × 10−8

2.40

7.45 × 10−5

0.063

11

rs4757260

0.30

0.26

0.87

0.06

0.38

6.01 × 10−8

2.43

5.82 × 10−5

0.063

11

rs12286075

0.32

0.36

0.93

0.28

0.32

5.98 × 10−8

2.20

4.92 × 10−5

0.063

11

rs4923182

0.42

0.46

0.98

0.70

0.24

1.12 × 10−8

2.51

4.12 × 10−6

0.067

11

rs4923186

0.42

0.46

0.99

0.85

0.24

1.83 × 10−8

2.50

5.04 × 10−6

0.066

12

rs10841420

0.44

0.46

0.89

0.07

0.29

5.66 × 10−8

2.13

5.78 × 10−5

0.064

12

rs10437774

0.43

0.44

0.90

0.09

0.31

1.05 × 10−7

2.09

8.46 × 10−5

0.063

13

rs9510242

0.33

0.31

1.08

0.23

0.96

0.790

0.43

8.02 × 10−5

0.063

15

rs16968382

0.03

0.05

0.81

0.15

0.50

6.47 × 10−7

4.09

9.73 × 10−5

0.062

15

rs8035166

0.36

0.35

0.85

0.01

0.34

9.47 × 10−8

2.15

8.29 × 10−5

0.063

20

rs12625552

0.03

0.06

0.85

0.23

0.47

2.19 × 10−7

3.99

2.87 × 10−5

0.064

  1. OR for odds ratio, P for P value and R2 for goodness of fit of logistic regression models.
  2. aOnly those suggestively significant SNPs with a Pinter < 1 × 10−4 were shown.
  3. bMAF for minor allele frequency in Chinese in 1000 Genomes, cMAF in this study controls.
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