Table 2 Gene Ontology (GO) pathway analysis of Y-hg O3e* interacted SNPs.

From: Y chromosome haplogroups based genome-wide association study pinpoints revelation for interactions on non-obstructive azoospermia

Index

Pathway enrichment

P

P FDR

1

Tob1 Pathway

<0.001

<0.001

2

Hematopoietin interferon classd200 domain cytokine receptor binding (GO:0005126)

<0.001

<0.001

3

Homeostasis of number of cells (GO:0048872)

0.001

0.003

4

Natural killer cell activation (GO:0030101)

<0.001

0.003

5

IL18 Pathway

<0.001

0.003

6

Lymphocyte activation (GO:0046649)

<0.001

0.006

7

Cell activation (GO:0001775)

0.001

0.007

8

Antigen processing and presentation of endogenous peptide antigen (GO:0002483)

0.001

0.007

9

Positive regulation of mononuclear cell proliferation (GO:0032946)

0.001

0.008

10

Lymphocyte proliferation (GO:0046651)

<0.001

0.008

11

Leukocyte activation (GO:0045321)

0.001

0.009

12

Regulation of cell growth (GO:0001558)

0.006

0.023

13

Antigen processing and presentation of peptide antigen via MHC class i (GO:0002474)

0.005

0.025

14

Regulation of mononuclear cell proliferation (GO:0032944)

0.007

0.031

15

T cell homeostasis (GO:0043029)

0.017

0.032

16

Regulation of blood pressure (GO:0008217)

0.010

0.034

17

Lymphocyte mediated immunity (GO:0002449)

0.017

0.044