Figure 1 | Scientific Reports

Figure 1

From: Prostate tumor attenuation in the nu/nu murine model due to anti-sarcosine antibodies in folate-targeted liposomes

Figure 1

Characterization of FA-modified liposomal formulations of sarcosine and antisarAbs.

(A) TEM micrograph (length of scale bar is 50 nm) and (B) dynamic light scattering analyzed in PBS, pH 7.4, with corresponding ζ potential inserted. (C) UV-Vis absorption spectrum of antisarAbs-bearing liposomes (λ = 270 nm corresponds to encapsulated antisarAbs, and λ = 365 nm corresponds to surface modification with FA) with the inserted photoluminescence spectra of liposomes before and after modification with FA (λexc = 360 nm). (D) Time dependence of the cellular uptake of QD-labeled antisarAbs@LIP into PC-3 cells obtained via inverted fluorescence microscopy (length of scale bar is 200 μm). Cells were incubated with 10 μM QD-labeled antisarAbs@LIP. (E) Competitive inhibitory effects in PC-3 cells. Values represent the mean ± SD of three experiments. Asterisks indicate significant differences (p < 0.05).

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