Figure 3
Effects of administration on the gene expression patterns.
(A) Venn diagram showing the overlapping genes that were up-regulated after both types of administration. (B) Representation of the relative expression levels of genes specific to any aspect of PC, which were significantly up- or down-regulated in post-treatment tumor tissues. GAB2 – Growth factor receptor-bound protein 2 (GRB2)-associated binding protein 2; SLC43A1 – Solute carrier family 43, member 1; KLK3 – Kallikrein 3 (prostate-specific antigen) PSA; KLK4 – Kallikrein 4 (prostase, enamel matrix, prostate); CCND1 – Cyclin D1, alpha polypeptide; TCF7 – Transcription factor 7 (T-cell specific, HMG-box); PART1 – Prostate androgen regulated transcript 1; PSCA – Prostate stem cell antigen; E2F3 – E2F transcription factor 3; PDGFRB – Platelet-derived growth factor receptor, beta polypeptide; BAX – Bcl2-associated X protein, TEGT – Transmembrane BAX inhibitor motif containing 6. Values are expressed as the mean of three independent replicates (n = 3). Vertical bars indicate standard error. Asterisks indicate significant differences (p < 0.05) compared to the group treated with empty liposomes. (C) Western blot analysis for the xenografts expression of caspase-3 and cleaved caspase-3.
