Table 1 Data fitting (see Fig. 1A) relative to the evaluation of the IC50 values of Cu(II) and Zn(II) ions for ChT-L, T-L and C-L peptidase activity of the CP.Curve fitting was performed by using Equation 1.

From: Copper(II) ions affect the gating dynamics of the 20S proteasome: a molecular and in cell study

 

ChT-L

T-L

C-L

Cu(II)

Zn(II)

Cu(II)

Zn(II)

Cu(II)

Zn(II)

IC50 (μM)

1.19

5.99

1.45

4.16

1.01

5.84

95% Confidence Intervals

0.67 to 2.09

2.98 to 12.30

0.98 to 2.14

1.65 to 10.53

0.66 to 1.56

4.94 to 6.90

R2

0.91

0.91

0.96

0.81

0.95

0.99

  1. Curve fitting was performed by using Equation 1.
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