Figure 4
From: Ablation of Y1 receptor impairs osteoclast bone-resorbing activity
Y1R deficiency inhibits the expression of essential bone-resorbing factors.
The proteolytic activity of MMP-9 in Y1R−/− osteoclasts was slightly diminished, as determined by gelatin zymography (A,B). In agreement, the mRNA expression levels of MMP-9 and CSTK were also downregulated in Y1R−/− cultures (C), which resulted in a trend towards decreased levels of released CTX-I (D). Data is expressed as mean ± SEM. **p < 0.01, ***p < 0.001 different from WT.
