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Figure 1

From: Complement component 3 deficiency prolongs MHC-II disparate skin allograft survival by increasing the CD4+ CD25+ regulatory T cells population

Figure 1

Local C3 deficiency prolonged MHC-II disparate skin allograft survival.

Mice were transplanted with full thickness tail skin from indicated donors, and transplant rejection was monitored. (a) Alloreactive C3+/+ B6 or C3−/− B6 skin grafts were transplanted into MHC-II disparate Bm12 recipient mice. Syngeneic Bm12 donors were used as negative controls (n = 6–15). (b) Bm12 mice skin grafts were transplanted into C3+/+ or C3−/− B6 recipient mice (n = 7–8). Data were obtained from two independent experiments.

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