Table 4 Comparison of phenotypic and genotypic drug resistance testing of HIV-1 strains.

From: A simple and cost-saving phenotypic drug susceptibility testing of HIV-1

  

Level of drug resistance

HIV-1 strain

Type

DDI

D4T

AZT

DDC

FTC

ABC

NVP

ETR

DPV

RPV

NFV

LPV

38290022

Phenotypic

1.22

1.6

17.7

1.38

>1000

6.7

>1000

5

7.85

12.2

0.34

0.9

Genotypic

H

NA

H

M

H

L

NA

S

S

38290063

Phenotypic

2.38

2

14.3

2.09

>1000

3.95

>1000

3.6

3.86

7.2

0.26

1.17

Genotypic

H

NA

H

H

L

NA

L

S

S

38290075

Phenotypic

>1000

51

>1000

74

>1000

97

>1000

645

>1000

215

2.98

1.57

Genotypic

H

H

H

NA

H

H

H

NA

S

S

38290079

Phenotypic

1.2

0.74

0.48

0.87

0.35

0.94

28

1.6

1.69

1.2

0.29

0.93

Genotypic

S

S

S

NA

S

S

H

S

NA

S

S

S

38290243

Phenotypic

1.1

1

0.4

1.75

1.85

0.8

4.23

15

8.83

7.32

1.04

2.46

Genotypic

S

S

S

NA

S

S

NA

S

S

38290306

Phenotypic

0.92

0.86

0.3

0.7

0.66

0.8

>1000

87

270

30.74

2.25

2.1

Genotypic

S

S

S

NA

S

S

H

NA

S

S

38290309

Phenotypic

1.07

1

1.4

1.07

0.97

0.74

0.5

2.7

1.37

2.08

1.35

2

Genotypic

S

S

S

NA

S

S

S

S

NA

S

S

S

38290312

Phenotypic

1.02

0.68

0.95

0.6

0.89

1.15

>1000

17.8

48.4

16.29

10

0.42

Genotypic

S

NA

S

S

H

NA

H

H

Wild type

Phenotypic

1

1

1

1

1

1

1

1

1

1

1

1

Genotypic

S

S

S

NA

S

S

S

S

NA

S

S

S

  1. NA, not available. Genotypic drug resistances are indicated by S (susceptible), L (low resistance), M (middle resistance) or H (high resistance) according to the database [Available at: http://hivdb. stanford.edu/; accessed on April 28, 2014 and February 20, 2016], of which capital letters in bold with “+” or “++” and underline indicate discrepancies between phenotypic and genotypic resistance for at least one or two levels, respectively. Phenotypic drug resistance is presented as the fold change (FC), of which FC < 3 indicates susceptibility, FC = 3- < 6 low resistance, FC = 6- < 10 middle resistance, FC ≥ 10 high resistance of drug to HIV-1 strains, respectively6,31,36.
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