Figure 7 | Scientific Reports

Figure 7

From: Transient receptor potential channel 1/4 reduces subarachnoid hemorrhage-induced early brain injury in rats via calcineurin-mediated NMDAR and NFAT dephosphorylation

Figure 7

Mechanism of the protective effect induced by TRPC1 and TRPC4 after SAH.

Following SAH, the expression of TRPC1/4 was increased, which in turn upregulated the activity of calcineurin (CN). CN promoted the dephosphorylation of NMDAR, which can restrict the early brain injury, including cortical death and degeneration due to SAH. With overexpression of TRPC1/4, more apparent protective effects were shown. With inhibition of TRPC1/4 (by inhibitor in vivo or by siRNA in vitro), EBI were aggravated. Activated CN promotes the nuclear transfer of NFAT, which in turn upregulates the expression of TRPC1/4. CHA: chlorogenic acid.

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