Figure 6 | Scientific Reports

Figure 6

From: Inhibition of hypothalamic MCT1 expression increases food intake and alters orexigenic and anorexigenic neuropeptide expression

Figure 6

Knockdown of MCT1 increases food intake and leads to a sustained intake over time.

(A) Scheme of the experimental protocol. Adult male rats were sterotaxically cannulated into the 3V. After 120 h of recovery, the rats were injected with AdshβGal or AdshMCT1. At 72 h post-adenoviral injection, the rats were subjected to 2  h of fasting followed by 24 h of feeding. Parameters, including food intake, body weight, glycemia and meal frequency, were measured. (B) Quantification of food intake by rats transduced with AdshβGal (open bars) or AdshMCT1 (closed bars) over 24 h after feeding were expressed as g/200 g body weight. (C) Percentage of change in body weight 24 h after feeding in rats transduced with AdshβGal (open bars) or AdshMCT1 (closed bars). (D) Quantification of glycemia after fasting in rats transduced with AdshβGal (open bars) or AdshMCT1 (closed bars). **p < 0.01 (*unpaired t-test).

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