Figure 7
MCT1 knockdown alters the satiety behavior.
(A–D) Rats were transduced with AdshβGal (open bars) or AdshMCT1 (closed bars). (A) Cumulative meal frequency over 24 h was determined. (B) Detailed analysis of meal frequency every 3 h in the dark phase. In controls, the meal frequency decreased while remaining relatively constant in shMCT1 animals. (C) Cumulative intermeal-intervals over 24 h were determined. (D) Quantification of intermeal-intervals every 3 h in the dark phase. In the controls, the duration of the intervals increased while remaining relatively constant in shMCT1 animals, suggesting that MCT1 knockdown disrupted satiety signaling. ANOVA: #p < 0.05, **p < 0.01 (*unpaired t-test), (#paired t-test).
