Figure 8
From: Liprin-α1 and ERC1 control cell edge dynamics by promoting focal adhesion turnover
Model for the role of the liprin-α1 and ERC1 on focal adhesion turnover.
During migration, liprin-α1 and ERC1 are recruited together at focal adhesions near the cell edge (a) displacing its cytoplasmic components (b), to facilitate the internalization of active integrins into Rab7-positive endosomes and promote focal adhesion tunover and protrusion (c). A defect in the recruitment of liprin/ERC functional complexes prevents efficient focal adhesion disassembly inhibiting protrusion.
