Figure 5
From: Circadian dynamics in measures of cortical excitation and inhibition balance
Dynamics of Neuronal excitation/inhibition and GABA/Glutamate receptor balance are related to cortical excitability and behavior.
Left panels: Cortical excitability, as indexed by the amplitude of the early (0–30 ms) TMS-evoked EEG response (z-scored; slope not shown) (A), performance to the visuo-motor vigilance task (z-scored mean distance to center of the screen) (B) and subjective sleepiness scores (z-scored) (C) significantly varied with time awake as reported in ref. 17. GABA/Glutamate receptor time constant (middle panels) and cell-to-cell excitation/inhibition connectivity (right panels) balances significantly correlated with cortical excitability (A), performance to the visuo-motor vigilance task (B) and subjective sleepiness scores (C). In all correlations, n = 22 and blue and red lines correspond, respectively, to 80% and 70% of data (prediction ellipses); r and p values are displayed on each panel.
