Table 1 Characteristics of studies included in genetically engineered mouse models.

From: Effect of Intermittent versus Chronic Calorie Restriction on Tumor Incidence: A Systematic Review and Meta-Analysis of Animal Studies

Source

Group

Tumor characteristics

IGF-1, ng/ml

Leptin, ng/ml

Adiponectin, μg/ml

No. with tumor/subjects

Age at detection, week

No. of tumors/animal

Weight, g

Berrigan28

ICR

24/31

NA

NA

NA

473 ± 54.1

14.7 ± 3.7

NA

 

CCR

27/31

NA

NA

NA

412 ± 24.1

4.8 ± 1.7

NA

Cleary23

ICR

1/30

80

1.0

0.06

553.6 ± 37.5

NA

NA

 

CCR

15/33

73.5 ± 2.2

1.7 ± 0.3

0.67 ± 0.13

467.7 ± 22.5

NA

NA

Pape-Ansorge34

ICR

7/31

56.9 ± 6.7

1.3 ± 0.2

1.29 ± 0.27

626 ± 16

NA

NA

 

CCR

11/33

54.0 ± 4.1

1.7 ± 0.2

1.69 ± 0.16

567 ± 21

NA

NA

Cleary22

ICR

6/39

79.4 ± 0.3

1.6 ± 0.4

0.48 ± 0.25

R:369 ± 28 RF:457 ± 22

NA

NA

 

CCR

11/30

74.5 ± 2.6

1.8 ± 0.4

0.24 ± 0.09

383 ± 20

NA

NA

Bonorden29

ICR

92/101

38

NA

NA

R:296.9 ± 18.4* RF:322.7 ± 14.8*

R:1.2 ± 0.2* RF:2.8 ± 0.3*

R:18.3 ± 1.9* RF:16.2 ± 1.7*

 

CCR

75/79

35

NA

NA

388.8 ± 12.2*

2.6 ± 0.3*

11.4 ± 0.8*

Rogozina26

ICR

6/66

67.0 ± 4.2

1.0

0.66 ± 0.38

R:476.8 ± 38.9* RF:656.8 ± 29.2*

NA

NA

 

CCR

23/65

69.0 ± 1.6

1.39 ± 0.2

0.43 ± 0.04

630.9 ± 27.8*

NA

NA

Dogan31

ICR

6/52

55

NA

NA

R:195 ± 6 RF:211 ± 21

R:2.6 ± 0.4 RF:2.9 ± 0.7

R:25.1 ± 3.5 RF:17.5 ± 2.2

 

CCR

8/40

37

NA

NA

298 ± 21

5.4 ± 1.1

14.7 ± 1.2

Lanza-Jacoby32

ICR

4/15

NA

NA

NA

284.1 ± 17.9

1.2 ± 0.2

9.9 ± 0.6

 

CCR

6/15

NA

NA

NA

226.4 ± 12.2

0.9 ± 0.2

9.7 ± 0.6

Mizuno33

ICR

17/29

49.1

NA

1.4

386.5 ± 73.6*

0.8 ± 0.3*

7.4 ± 0.2*

 

CCR

17/36

52.4

NA

1.5

656.4 ± 49.1*

3 ± 0.6*

6.2 ± 0.5*

Rogozina27

ICR

2/45

82.0 ± 0.0

1.0 ± 0.001

0.05 ± 0.0

R:231.4 ± 66.0* RF:382.6 ± 22.7*

R:3.2 ± 2.1* RF:13.2 ± 8.7*

R:11.5 ± 4.4* RF:8.1 ± 4.3*

 

CCR

23/44

74.5 ± 1.6

1.7 ± 0.16

0.75 ± 0.24

305.2 ± 19.6*

11.0 ± 10.1*

11.2 ± 5.9*

Grossmann30

ICR

12/30

NA

NA

NA

NA

NA

NA

 

CCR

17/33

NA

NA

NA

NA

NA

NA

  1. Values are means ± SE.
  2. CCR: chronic calorie restriction; ICR: intermittent calorie restriction; IGF-1: insulin-like growth factor 1; NA: not available; R: results of ICR restriction periods; RF: results of ICR refeeding periods; SE: standard error.
  3. *Data were extracted from the original figures using GetData Graph Digitizer.
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