Table 3 Standardised mean differences in other tumor relative indexes comparing ICR to CCR in two animal models.

From: Effect of Intermittent versus Chronic Calorie Restriction on Tumor Incidence: A Systematic Review and Meta-Analysis of Animal Studies

Indexes

No. of studies

No. of subjects (ICR/CCR)

SMD (95% CI)

Heterogeneity test

Genetically engineered mouse model

Age at detection

3

19/45

0.17 (−0.38, 0.72)

P = 0.40, I2 = 0.0%

No. of tumors/animal

3

15/45

−0.51 (−1.14, 0.12)

P = 0.65, I2 = 0.0%

Tumor weight

3

19/45

0.15 (−0.65, 0.94)

P = 0.13, I2 = 50.2%

Chemically induced rat model

No. of tumors/animal

2

57/53

0.63 (−1.31, 2.57)

P < 0.00, I2 = 95.2%

  1. All the pooled estimates were obtained using a random-effects model.
  2. CCR: chronic calorie restriction; CI: confidence interval; ICR: intermittent calorie restriction; SMD: standardised mean difference.
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