Table 3 Correlation between imaging score and treatment response after NAC (n = 48, pCR = pathological complete response.

From: Three-dimensional Contrast-enhanced Ultrasound in Response Assessment for Breast Cancer: A Comparison with Dynamic Contrast-enhanced Magnetic Resonance Imaging and Pathology

 

pCR Mean ± SD (range)

non-pCR Mean ± SD (range)

p value

r

MHR Mean ± SD (range)

NMHR Mean ± SD (range)

p value

r

3D-CEUS score

0.5 ± 1.4 (0–4)

3.9 ± 1.7 (1–8)

0.0001

−0.573

2.1 ± 1.7 (0–4)

4.2 ± 1.9 (1–8)

0.0002

−0.541

DCE-MRI score

0.3 ± 0.7 (0–2)

3.9 ± 1.9 (0–8)

<0.0001

−0.615

1.5 ± 1.5 (0–4)

4.6 ± 1.6 (2–8)

<0.0001

−0.702

Δ3D-CEUS

8.1 ± 1.1 (6–9)

3.4 ± 1.5 (2–6)

<0.0001

0.649

6.5 ± 1.7 (4–9)

2.6 ± 0.7 (2–4)

<0.0001

0.863

ΔDCE-MRI

8.0 ± 1.1 (7–9)

3.5 ± 1.7 (1–7)

<0.0001

0.639

6.4 ± 1.6 (5–9)

2.7 ± 1.2 (1–5)

<0.0001

0.836

  1. MHR = major histological response. NMHR = non-major histological response. DCE-MRI = dynamic contrast enhanced magnetic resonance imaging. 3D-CEUS = three dimensional contrast enhanced ultrasound. Δ3D-CEUS = score difference before and after treatment. ΔDCE-MRI = score difference before and after treatment).