Table 1 In vivo metabolism of DON to DON-3-sulfate in an eight-day duplicate diet case study19.

From: Identification of a novel human deoxynivalenol metabolite enhancing proliferation of intestinal and urinary bladder cells

 

DON intake a in μg/d and (μmol/d)

Urine excretion [L]

DON-3-sulfate b [μg/L]

DON-3-sulfate b in μg/d and (μmol/d)

D3S excretion rate [%] c

Day 1

—

2.2

n.d.

n.d.

n.d.

Day 2

—

1.8

n.d.

n.d.

n.d.

Day 3

138 (0.47)

2.2

2.8

6.0 (0.02)

4.3

Day 4

138 (0.47)

2.7

1.0

2.8 (0.01)

2.1

Day 5

138 (0.47)

2.3

2.2

4.8 (0.02)

3.5

Day 6

138 (0.47)

2.5

2.3

5.9 (0.02)

4.3

Day 7

—

2.4

n.d.

n.d.

n.d.

Day 8

—

1.6

n.d.

n.d.

n.d.

Average

138 (0.47)

2.4

2.1

4.9 (0.02)

3.5

  1. A ‘high DON diet’ predominantly consisting of contaminated cereals was consumed during days 3–6 while days 1–2 and 7–8 were clearing periods.
  2. aDaily DON intake without taking masked forms (3-acetyl DON, 15-acetyl-DON, DON-3-glucoside) into account.
  3. bExpressed as DON equivalents.
  4. cExcretion rate was calculated as follows: Excreted quantity DON-3-sulfate in μmol/DON intake in μmol * 100.
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