Figure 4

Food and water intake, urine flow and urine osmolarity data: (a) 24-hour food consumption, (b) water intake, (c) urine flow and (d) urine osmolarity in control () and water-restricted (
) SHR at baseline and at the end of the 4-week water restriction protocol. (e,f) The 24-hour urine flow and osmolarity data for the post-treatment collection period are replotted as the first 8 hours and final 16 hours. Data are presented as mean ± SEM and were analyzed using repeated-measures ANOVA with Bonferroni’s post-hoc tests (2 comparisons). *P ≤ 0.05 and ***P ≤ 0.001 versus baseline or 8 hours. #P ≤ 0.05, ##P ≤ 0.01 and ###P ≤ 0.001 versus control SHR. n = 8–13 per group.