Figure 2: Voxel-wise correlation analyses using the right caudoputamen as a seed area.

(a) Seed area (right caudoputamen) is shown as the white area on the VOI template. (b) In the control group, the both caudoputamen, both motor cortices, both visual cortices and the right cerebellum showed correlations with the right caudoputamen using a lenient criterion of uncorrected p < 0.001 (overlaid image with blue color). (c) By contrast, in the PD group, only the both caudoputamen, and both motor cortices showed a tendency toward correlation with the right caudoputamen using the same lenient criterion of uncorrected p < 0.001 (overlaid image with red color). (d) Z-score differences over 2.57 (uncorrected p < 0.01) between the two correlation maps from the PD and control groups are displayed in the images. The left caudoputamen, right visual cortex, and right cerebellum showed a tendency toward decreased correlation with the right caudoputamen in the PD group compared with the control group.