Figure 1: Identification of the Gefitinib binding pocket in EGFR kinase domain. | Scientific Reports

Figure 1: Identification of the Gefitinib binding pocket in EGFR kinase domain.

From: Identification of gefitinib off-targets using a structure-based systems biology approach; their validation with reverse docking and retrospective data mining

Figure 1

(A) Schematic illustration of EGFR receptor on the cell membrane. (B) The gefitinib binding pocket was calculated at the distance of 3 Å using Maestro. The identified ligand binding pocket is shown in 2D. Residues are colored according to their properties (red, negatively charged; blue, positively charged; cyan, polar; green, hydrophobic; and white, neutral). The H-bond is shown with magenta arrow.

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