Figure 4: Comparison of the binding energies of gefitinib (∆Ggef) and the respective bound ligand (∆Glig) with the off-target structures. | Scientific Reports

Figure 4: Comparison of the binding energies of gefitinib (∆Ggef) and the respective bound ligand (∆Glig) with the off-target structures.

From: Identification of gefitinib off-targets using a structure-based systems biology approach; their validation with reverse docking and retrospective data mining

Figure 4

The ratio of gefitinib and reported ligand binding energies (∆Ggef/∆Glig) were plotted against the average binding energy of both. The dotted line shows the threshold ratio 1.5. The spheres with read colour show the significant ratio above the threshold value.

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