Figure 4: DNA methylation in primary AML samples. | Scientific Reports

Figure 4: DNA methylation in primary AML samples.

From: Expression of immunoproteasome genes is regulated by cell-intrinsic and –extrinsic factors in human cancers

Figure 4

(a) Boxplots of log10 [1000 × RPKM + 1] values for the indicated genes in FAB M3 and M5 AMLs. Differences between means were determined by Student’s t-test. *Indicates p < 0.05. (b–d) Correlation coefficient between mRNA expression of (b) PSMB8, (c) PSMB9 and (d) PSMB10 and intensity of DNA methylation on cytosines located near coding sequences of PSMB8/9/10 for all AML TCGA samples. Arrows indicates direction of transcription. TSS: Transcription Start Site.

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