Figure 4 | Scientific Reports

Figure 4

From: Rescue of Early bace-1 and Global DNA Demethylation by S-Adenosylmethionine Reduces Amyloid Pathology and Improves Cognition in an Alzheimer’s Model

Figure 4

Effect of SAM administration on AD-like amyloid pathology.

(A) Intense intraneuronal Aβ immunoreactivity is observed in Tg mice throughout the neocortex (a–d), hippocampus (a–f) and subiculum (g,h), as revealed with the anti-Aβ McSA1 monoclonal antibody. Note the absence of McSA1-immunoreactivity in non-transgenic animals (i). Scale bar: a-b, i = 500 μm; c-d = 100 μm; e-h = 50 μm. (B) Quantification of the total number of extracellular Aβ-amyloid plaques. (C) Quantification of the intensity of intraneuronal McSA1 immunoreactivity in cortical lamina V, presented as arbitrary units (A.U.). Data are expressed as mean ± SEM and analyzed with Student’s t-test. *p < 0.05, **p < 0.01, ***p < 0.001.

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