Table 1 Immunohistochemical detection of p53 in patient tumors suggests alterations in cSCCHN with clinical PNI.

From: Expression profiling of cutaneous squamous cell carcinoma with perineural invasion implicates the p53 pathway in the process

Staining Pattern

cSCCHN (%)

cSCCHN Incidental PNI (%)

P

cSCCHN Clinical PNI (%)

P

n = 27

n = 27

n = 31

Normal

4 (14.8%)

5 (18.5%)

0.2599

0 (0%)

<0.0001

Diffuse Overexpression

11 (40.7%)

9 (33.3%)

 

18 (58.1%)

 

Focal/Restricted Overexpression

9 (33.3%)

9 (33.3%)

 

6 (19.4%)

 

Negative

3 (11.1%)

4 (14.8%)

 

7 (22.6%)

 
  1. Staining of p53 was assessed according to previously published studies21 by a histopathologist (I.B.) blinded to the study hypothesis. Chi-squared test was used to assess differences in groups, data was considered statistically significant when P ≤ 0.05.
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