Figure 7: Rad51 RNAi treatment induced mitochondrial malfunction and mitophagy and subsequently incomplete cytokinesis during oocyte meiosis. | Scientific Reports

Figure 7: Rad51 RNAi treatment induced mitochondrial malfunction and mitophagy and subsequently incomplete cytokinesis during oocyte meiosis.

From: The role of Rad51 in safeguarding mitochondrial activity during the meiotic cell cycle in mammalian oocytes

Figure 7

Rad51 silencing-induced mitochondrial malfunction led the decreased ATP production and reduced ΔΨm in oocytes. Rad51-silenced oocytes had markedly fewer mitochondria as a result of the activation of mitophagy. In addition, abnormal spindle aggregation and chromosomal misalignment caused by low mitochondrial quality and quantity resulted in cytokinesis failure; as a result, Rad51-silenced oocytes were mainly arrested at MI.

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