Table 2 Univariate analysis of risk factors for three-year DFS and OS.

From: Time to lowest postoperative carcinoembryonic antigen level is predictive on survival outcome in rectal cancer

Risk Factor

Disease-free Survival

Overall Survival

3-year DFS rate (%)

HR (95% CI)

p-value

3-year OS rate (%)

HR (95% CI)

p-value

AJCC Stage III

62.2

4.06 (2.27–7.23)

<0.001

75.8

5.19 (2.23–12.10)

<0.001

AJCC Stage II

78.7

2.05 (1.08–3.89)

0.027

82.3

3.17 (1.29–7.74)

0.012

Low-grade differentiation

61.4

2.32 (1.37–3.93)

0.002

72.5

4.28 (1.93–9.50)

<0.001

Vascular invsion

53.1

2.32 (1.50–3.58)

<0.001

67.3

2.30 (1.31–4.03)

0.004

Perineural invasion

37.8

3.60 (2.27–5.69)

<0.001

70.0

2.41 (1.27–4.59)

0.007

Distance from anal verge <5 cm

69.4

1.50 (1.06–2.13)

0.022

77.1

1.58 (1.02–2.47)

0.043

Preoperative elevated CEA

65.3

1.46 (1.01–2.09)

0.044

71.2

2.22 (1.40–3.50)

0.001

TTDpR

 

1.13 (1.06–1.22)

0.001

 

1.17 (1.07–1.29)

0.001

 </ = 4.5 weeks

81.4

0.55 (0.29–1.04)

0.065

95.8

0.35 (0.12–0.97)

0.048

 >4.5 weeks

76.2

1

 

87.9

1

 
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