Figure 2: Electrophysiological features of LQTS3/BrS iPSC-derived cardiomyocytes.
From: Embryonic type Na+ channel β-subunit, SCN3B masks the disease phenotype of Brugada syndrome
(A,B) Representative MEA recordings from control and LQTS3/BrS iPSC-derived beating EBs. FP, field potential. (C) Rate of beating of control and LQTS3/BrS iPSC-derived EBs. (D) Average corrected field potential duration (cFPD) recorded with the MEA in control (n = 6) and LQTS3/BrS iPSC-derived (n = 7) beating EBs. (E) Representative action potentials of control and LQTS3/BrS iPSC-derived cardiomyocytes showing nodal-, atrial- and ventricular-type morphology, recorded in spontaneous firing cardiomyocytes. The dashed line indicate 0 mV. (F) Statistical parameters of action potential duration at 90% repolarization (APD90) obtained from control and LQTS3/BrS iPSC-derived cardiomyocytes exhibiting nodal- (n = 6 and 19, respectively), atrial- (n = 6 and 4, respectively) and ventricular-type (n = 10 and 7, respectively) morphology. Where appropriate, data are given as the mean ± SEM. *P < 0.05 compared with control.
