Figure 3: Electrophysiological features of LQTS3/BrS iPSC-derived cardiomyocytes, as determined by patch-clamp analyses.
From: Embryonic type Na+ channel β-subunit, SCN3B masks the disease phenotype of Brugada syndrome
(A) Representative current traces of baseline in control and LQTS3/BrS iPSC-derived cardiomyocytes. (B) The average and data plots of peak current, late current, and relative late current in control (n = 22) and LQTS3/BrS iPSC-derived cardiomyocytes (n = 21). (C) Representative current traces of baseline in control and LQTS3/BrS iPSC-derived cardiomyocytes. The pulse protocol is shown in the upper panel. (D) Average current–voltage relationship for peak current in control (n = 9) and LQTS3/BrS iPSC-derived cardiomyocytes (n = 10). (E) Average voltage-dependent activation and inactivation curves in control (n = 9, 4 respectively) and LQTS3/BrS iPSC-derived cardiomyocytes (n = 10, 7 respectively). Where appropriate, data are given as the mean ± SEM.
