Figure 4: Growth plate defects in a patient with mutations in IFT81. | Scientific Reports

Figure 4: Growth plate defects in a patient with mutations in IFT81.

From: Destabilization of the IFT-B cilia core complex due to mutations in IFT81 causes a Spectrum of Short-Rib Polydactyly Syndrome

Figure 4

(A) X-ray of formalin fixed distal femur at 19 months of age showing irregular metaphyseal margin (arrow). (B,C) Picrosirius Red-Haematoxylin staining of same distal femur (B) magnified in (C) showing irregular hypertrophic column formation and lack of normal progressive enlargement of hypertrophic chondrocytes. Arrow points to an irregular collagenous band transecting the growth plate. (D,E) Differences between control and IFT81 defective growth plates. (D) Control. (E) R98-443. Bone is represented in red and cartilage in blue.

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